On the case of joint investigation with the Geological Survey of Japan in the survey on the Paleogene-Quartenary geology of the Mekong Delta, a test of the application of the multichannel high-resolution seismic reflection was carried out over some rivers and canals of this delta. The field data was collected using the seismograph Mark - 6, working with 8 channels, with the vibration source from a boomer of 300 J and the hydrophone array in grouping of 3 pieces per channel. The survey tracks cover all typical hydrologic and geologic conditions of the delta, such as the deep (over 5 m) and shallow water (under 2 m), and the expected fault zone. The results appear to be good for discovering the seismo-geologic layers down to ca. 70 m, and occasionally to 120 m (160 ms travel time), as well as locating the fault zones under the riverbed.